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. 2016 Apr 20;7(21):31177–31190. doi: 10.18632/oncotarget.8870

Figure 2. ZNF224 increases cell growth and apoptosis resistance.

Figure 2

A and B. ZNF224 over-expression cell line or ZNF224 knock-down cell line was seeded into iCelligence chamber and cultured for 10 h. Then CPT (0.1 μM) was treated, and cell growth was analyzed. Data are from at least three independent experiments (n=3). C and D. ZNF224 over-expression cell line or ZNF224 knock-down cell line was treated with CPT (0.1 μM) for 24 h, and subG1 population was analyzed as described in the Methods section. Data are from at least three independent experiments (n=3). E and F. ZNF224 over-expression cell line or ZNF224 knock-down cell line was treated with CPT (0.1 μM) in a time-dependent manner. Protein extracts were subjected to SDS-PAGE to analyze PARP1 cleavage. Tubulin was used as a loading control.