Table 2. Treatment response and serum IGF1 level according to genotype of insulin-like growth factor axis genotype.

Locus	Genotype	ORR*	%	P	IGF1 (ng/ml)#	P
IGF1 rs4764887	AA	5/8	62.5	0.051	34.9 ± 29.5	0.790
	AG	19/75	25.3		40.5 ± 30.4
	GG	40/107	37.4		36.2 ± 32.0
IGF1R rs12423791	CC	5/6	83.3	0.010	32.1 ± 33.3	0.820
	CG	21/81	25.9		39.9 ± 29.3
	GG	38/103	36.9		36.6 ± 32.7
IGF1 rs2162679	AA	33/81	40.7	0.019	35.6 ± 30.7	0.841
	AG	22/92	23.7		39.4 ± 33.2
	GG	9/17	52.9		39.0 ± 37.8
IGF1 rs5742612	CC	7/9	77.8	0.016	23.9 ± 13.5	0.108
	CT	24/86	27.9		45.2 ± 33.5
	TT	33/62	53.2		37.8 ± 31.1
IGF1 rs35767	CC	33/82	40.2	0.005	35.1 ± 30.5	0.597
	CT	22/93	23.7		41.0 ± 33.3
	TT	9/15	60.0		32.5 ± 18.6

^*by Fisher's exact and chi-square test;

^#mean ± standard deviation; ORR, overall response rate.