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. 2016 Apr 21;7(21):31322–31335. doi: 10.18632/oncotarget.8900

Figure 3. TET1 suppresses tumor progress by up regulating PTEN.

Figure 3

A & B. TET1 increased mRNA levels of PTEN, p53, hMLH1 and IRX1. C. TET1 knockdown increased p-AKT and p-FAK (left), while PTEN re-expression decreased p-AKT and p-FAK level (right). D. Would healing assay of rescued effect by PTEN re-expression in TET1 KD cells. E. PTEN re-expression in TET1 KD cells inhibited cell migration and invasion. * p<0.05; ** p<0.01.