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Staining of individual colorectal cancer cases indicates loss of E-Cadherin (CDH1) expression in tumor cells with strong CYB5R1 expression (upper panels), and co-localization of CYB5R1 with Laminin gamma 2 (LAMC2, lower panels). Arrowheads indicate infiltrative colon cancer cells at the leading tumor edge. Asterisks indicate tumor cells with glandular differentiation. Right panels show composites of left and mid panels.
