Table 3. Multivariate Cox regression analysis of DAB2IP CpG1 with overall survival in the three sets.
| Parameters | TCGA set | MCHC set | UTSW set | |||
|---|---|---|---|---|---|---|
| P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | |
| Age (year) | 0.004 | 1.03 (1.01-1.05) | 0.004 | 1.03 (1.01-1.05) | 0.003 | 1.04 (1.01-1.06) |
| T (T1 vs T2 vs T3 vs T4) | 0.008 | 1.45 (1.10-1.90) | 0.226 | 1.22 (0.88-1.68) | 0.093 | 1.40 (0.95-2.07) |
| N (N0 vs N1) | - | - | <0.0001 | 5.05 (2.29-11.13) | 0.065 | 2.17 (0.95-4.93) |
| M (M0 vs M1) | 0.0001 | 2.52 (1.57-4.04) | 0.0001 | 13.38 (3.53-50.77) | 0.035 | 2.28 (1.06-4.88) |
| Grade (G1 vs G2 vs G3 vs G4) | 0.002 | 1.69 (1.22-2.34) | 0.139 | 1.29 (0.92-1.79) | 0.013 | 1.74 (1.13-2.70) |
| DAB2IP (methylation level) | 0.044 | 1.02 (1.00-1.04) | 0.005 | 1.02 (1.01-1.04) | 0.001 | 1.04 (1.02-1.06) |