Table V.
Percentage sequence difference between autologous plasma HIV-1 p24 clones and the HXB.2 sequence, and relationship to magnitude and breadth of HXB.2 strain p24-specific CD4+ T cell reactivity.
| Subject | Median difference from HXB.2a | p24-specific CD4+ T cell responses |
|
|---|---|---|---|
| Magnitude | # targets | ||
| UH156 | 23.5 (10.2%) | 1778 | 5 (4) |
| UH168 | 8 (3.5%) | 823 | 4 (3) |
| UH178 | 7.5 (3.2%) | – | 0 |
| UH185 | 3 (1.3%) | 3448 | 1 |
| UH200 | 5.5 (2.4%) | 8704 | 10 (7) |
| UH202 | 10 (4.3%) | NAb | 6 (5) |
| UH208 | 5 (2.2%) | – | 0 |
| UH210 | 2 (0.9%) | – | 0 |
| UH212 | 12 (5.2%) | – | 0 |
a
Number (percentage) of 231 amino acid residues not identical to the equivalent positions in the HXB.2 strain sequence of Gag p24. Value shown is the median from the 5-10 molecular clones from each subject’s plasma.
b
NA, not attempted.