FIGURE 1.
A consort flow diagram of this study. H. pylori eradication program adopted quadruple therapy (rabeprazole + bismuth potassium citrate + 2 kinds of antibiotics). Antibiotics include amoxicillin, clarithromycin, metronidazole, levofloxacin, and furazolidone. Patients in control group received empirical therapy (rabeprazole + bismuth potassium citrate + amoxicillin + clarithromycin, twice daily for 14 days), whereas patients in test group received individualized eradication program (rabeprazole + bismuth potassium citrate + 2 kinds of relatively sensitive antibiotics, twice daily for except for levofloxacin once daily for 14 days) based on the result of E-test. All the 90 patients accepted 13C-urea breath test after 4 to 6 weeks when treatment finished, negative results means successful eradication.