Skip to main content
. 2016 Oct 7;95(40):e5085. doi: 10.1097/MD.0000000000005085

Figure 4.

Figure 4

Inhibition of ADAM28 reduces IGFBP-3 cleavage, while overexpression of ADAM28 in DU145 human prostate cancer cells elevates IGF-1, but not IL-6 expression. (A) IGFBP-3 cleavage is inhibited by the ADAM inhibitor KB-R7785. (B) IGF-1 is significantly increased when ADAM28 is overexpressed. (C) There is no change in the expression of IL-6 when ADAM28 is over expressed; n = 6–9 samples per treatment. Data are presented as mean ± SEM. ∗P = 0.03. ADAM = a disintegrin and metalloproteinase, IGF = insulin-like growth factor, IGFBP-3 = IGF binding protein-3, IL-6 = interleukin 6, SEM = standard error of mean.