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. 2016 Sep 19;5:e19127. doi: 10.7554/eLife.19127

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© 2016, Wang et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — All embryos were generated by crossing WT/WT females with Xist^Δ/Y males. (A) Gender determination of embryos via Y-linked gene expression. As example, the distributions of reads at the 8-cell stage of Y-linked genes are shown in a box-plot. (B) Heat map representing Log₂ transformed data comparing the mRNA expression level ratios from chromosomes (excluding Y) between female and male embryos during pre/peri-implantation development. Chromosomes are indicated. (C) Developmental profile of X-silencing during iXCI in Xist^WT/Δp females as determined by comparing F/M expression of X-linked transcripts. Data were processed as described for those obtained for the WT/RlimKO dataset which were incorporated for comparison as dotted lines (see Figure 3A). (D) Comparison of F/M values for Xist^WT/Δp and Rlim^Δ/Δ with those obtained for WT/WT (set to 1). P values of P<0.05 are indicated (paired t-test).

DOI: http://dx.doi.org/10.7554/eLife.19127.010

Figure 5—figure supplement 1. — All embryos were generated by crossing WT/WT females with Xist^Δ/Y males. (A) Gender determination of embryos via Y-linked gene expression. As example, the distributions of reads at the 8-cell stage of Y-linked genes are shown in a box-plot. (B) Heat map representing Log₂ transformed data comparing the mRNA expression level ratios from chromosomes (excluding Y) between female and male embryos during pre/peri-implantation development. Chromosomes are indicated. (C) Developmental profile of X-silencing during iXCI in Xist^WT/Δp females as determined by comparing F/M expression of X-linked transcripts. Data were processed as described for those obtained for the WT/RlimKO dataset which were incorporated for comparison as dotted lines (see Figure 3A). (D) Comparison of F/M values for Xist^WT/Δp and Rlim^Δ/Δ with those obtained for WT/WT (set to 1). P values of P<0.05 are indicated (paired t-test).

DOI: http://dx.doi.org/10.7554/eLife.19127.010