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. 2016 Sep;8(9):E918–E927. doi: 10.21037/jtd.2016.08.93

Figure 3.

Figure 3

miRNAs modulation in direct cardiac reprogramming. The overexpression of cardiac-enriched miRNA-1, miRNA-133, miRNA-208, and miRNA-499 in combination with inhibitor of the Janus kinase pathway could directly reprogram fibroblasts into cardiac-phenotyped cells in vitro. By adding the combination of miRNA-1 and miRNA-133, the efficiency of four human cardiac transcription factors-based direct reprogramming was significantly enhanced.