Table S4. Correlations among immunohistochemical stainings (first line: correlation coefficient; second line: correspondent P value).
Correlations | CD117 | CD5 | p63 | p40 | p21n | p21c | p27n | p27c | p53 | Bcl-2 | Ki67 | Podoplanin | Synaptophysin | PTEN | Pax8n | Pax8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CD117 | 1 | Pos | Neg | Neg | Pos | Pos | Pos | Pos | Pos | Pos | Pos | Pos | Pos | Pos | ||
0.005 | 0.892 | 0.446 | 0.090 | 0.090 | 0.022 | 0.047 | 0.190 | <0.001* | 0.105 | 0.368 | 0.045* | 0.069 | 0.353 | 0.018* | ||
CD5 | Pos | 1 | 0.049 | 0.058 | 0.445 | 0.467 | 0.534 | 0.463 | 0.149 | 0.583 | 0.477 | Pos | Pos | −0.384 | 0.403 | 0.580 |
0.005* | 0.846 | 0.807 | 0.049* | 0.038* | 0.015* | 0.040* | 0.530 | 0.007* | 0.033* | 0.487 | 0.104 | 0.095 | 0.078 | 0.007* | ||
p63 | Neg | 0.049 | 1 | 0.816 | 0.026 | 0.364 | 0.514 | 0.560 | 0.112 | 0.138 | 0.173 | Neg | Pos | 0.577 | 0.588 | 0.497 |
0.892 | 0.846 | <0.001* | 0.918 | 0.137 | 0.029* | 0.016* | 0.657 | 0.584 | 0.492 | 0.101 | 0.389 | 0.012* | 0.010* | 0.036* | ||
p40 | Neg | 0.058 | 0.816 | 1 | −0.134 | 0.219 | 0.352 | 0.287 | 0.145 | 0.208 | 0.275 | Neg | Neg | 0.465 | 0.518 | 0.416 |
0.446 | 0.807 | <0.001* | 0.553 | 0.328 | 0.117 | 0.208 | 0.520 | 0.365 | 0.216 | 0.099 | 0.709 | 0.034* | 0.019* | 0.068 | ||
p21n | Pos | 0.445 | −0.026 | −0.134 | 1 | 0.538 | 0.429 | 0.462 | 0.272 | 0.815 | 0.469 | Pos | Pos | −0.319 | 0.228 | 0.333 |
0.010* | 0.049* | 0.918 | 0.553 | 0.010* | 0.052 | 0.035* | 0.220 | <0.001* | 0.028* | 0.253 | 0.546 | 0.159 | 0.334 | 0.152 | ||
p21c | Pos | 0.467 | 0.364 | 0.219 | 0.538 | 1 | 0.543 | 0.570 | 0.285 | 0.518 | 0.381 | Pos | Pos | 0.056 | 0.449 | 0.483 |
0.090 | 0.038* | 0.137 | 0.328 | 0.010* | 0.011* | 0.007* | 0.198 | 0.016 | 0.080 | 0.543 | 0.116 | 0.809 | 0.047* | 0.031* | ||
p27n | Pos | 0.534 | 0.514 | 0.352 | 0.429 | 0.543 | 1 | 0.806 | 0.155 | 0.624 | 0.511 | Pos | Pos | −0.104 | 0.815 | 0.887 |
0.022* | 0.015* | 0.029* | 0.117 | 0.052 | 0.011* | <0.001 | 0.503 | 0.002* | 0.018* | 0.140 | 0.136 | 0.654 | <0.001* | <0.001* | ||
p27c | Pos | 0.463 | 0.560 | 0.287 | 0.462 | 0.570 | 0.806 | 1 | 0.171 | 0.580 | 0.426 | Pos | Pos | 0.093 | 0.590 | 0.666 |
0.047* | 0.040* | 0.016* | 0.208 | 0.035* | 0.007* | <0.001* | 0.458 | 0.006* | 0.054 | 0.435 | 0.192 | 0.690 | 0.006 | 0.001 | ||
p53 | Pos | 0.149 | 0.112 | 0.145 | 0.272 | 0.285 | 0.155 | 0.171 | 1 | 0.346 | −0.008 | Pos | Pos | 0.167 | 0.289 | 0.261 |
0.190 | 0.530 | 0.657 | 0.520 | 0.220 | 0.198 | 0.503 | 0.458 | 0.125 | 0.972 | 0.340 | 0.332 | 0.470 | 0.217 | 0.266 | ||
Bcl-2 | Pos | 0.583 | 0.138 | 0.208 | 0.815 | 0.518 | 0.624 | 0.580 | 0.346 | 1 | 0.548 | Pos | Pos | −0.271 | 0.391 | 0.605 |
<0.001* | 0.007* | 0.584 | 0.365 | <0.001* | 0.016 | 0.002 | 0.006* | 0.125 | 0.010* | 0.377 | 0.115 | 0.235 | 0.088 | 0.005* | ||
Ki67 | Pos | 0.477 | 0.173 | 0.275 | 0.469 | 0.381 | 0.511 | 0.426 | −0.008 | 0.548 | 1 | Pos | Neg | −0.022 | 0.419 | 0.552 |
0.105 | 0.033* | 0.492 | 0.216 | 0.028* | 0.080 | 0.018* | 0.054 | 0.972 | 0.010* | 0.113 | 0.365 | 0.926 | 0.066 | 0.012* | ||
Podoplanin | Pos | Neg | Neg | Pos | Pos | Pos | Pos | Pos | Pos | Pos | 1 | 1 | Neg | Pos | Pos | |
0.368 | 0.487 | 0.101 | 0.099 | 0.253 | 0.543 | 0.140 | 0.435 | 0.340 | 0.377 | 0.113 | 0.259 | 0.260 | 0.134 | |||
Synaptophysin | Pos | Pos | Neg | Pos | Pos | Pos | Pos | Pos | Pos | Neg | 1 | 1 | Neg | Pos | Pos | |
0.045* | 0.104 | 0.389 | 0.709 | 0.546 | 0.116 | 0.136 | 0.192 | 0.332 | 0.115 | 0.365 | 0.654 | 0.663 | 0.183 | |||
PTEN | Neg | −0.384 | 0.577 | 0.465 | −0.319 | 0.056 | −0.104 | 0.093 | 0.167 | −0.271 | −0.022 | Neg | Neg | 1 | 0.126 | −0.029 |
0.069 | 0.095 | 0.012* | 0.034* | 0.159 | 0.809 | 0.654 | 0.690 | 0.470 | 0.235 | 0.926 | 0.259 | 0.654 | 0.595 | 0.904 | ||
Pax8n | Pos | 0.403 | 0.588 | 0.518 | 0.228 | 0.449 | 0.815 | 0.590 | 0.289 | 0.391 | 0.419 | Pos | Pos | 0.126 | 1 | 0.877 |
0.353 | 0.078 | 0.010* | 0.019* | 0.334 | 0.047* | <0.001* | 0.006* | 0.217 | 0.088 | 0.066 | 0.260 | 0.663 | 0.595 | <0.001 | ||
Pax8c | Pos | 0.580 | 0.497 | 0.416 | 0.333 | 0.483 | 0.887 | 0.666 | 0.261 | 0.605 | 0.552 | Pos | Pos | −0.029 | 0.877 | 1 |
0.018* | 0.007* | 0.036* | 0.068 | 0.152 | 0.031* | <0.001 | 0.001 | 0.266 | 0.005* | 0.012* | 0.134 | 0.183 | 0.904 | <0.001 |
*, significant P value (<0.05). n, nuclear staining; c, cytoplasmic staining; Pos, positive correlation in the Mann-Whitney-U-test; Neg, negative correlation in the Mann-Whitney-U-test.