Table 3. Antiviral effects of frHibis on various H5N1 HPAIVs (pre-treatment test).
| Virus | Treatment time after mixing the virus with the extracta) | |
|---|---|---|
| Log10 reduction in the titerb) | ||
| 10 min | Immediatelyc) | |
| Chicken/Yamaguchi/7/04 | ≥5.0d) | ≥5.0 |
| Whooper swan/Hokkaido/1/08 | ≥5.0 | 3.0 |
| Chicken/Miyazaki/K11/07 | ≥6.3 | ≥7.0 |
| Whooper swan/Hamanaka/11 | ≥5.0 | 3.8 |
| Chicken/VN-HT/33/2003 | ≥5.0 | ≥4.7 |
| Molly duck/VN-HN/77/07 | ≥5.2 | 2.7 |
| Chicken/VN-HT/30/10 | ≥5.0 | 2.0 |
a) The virus was mixed with frHibis (treated) or medium (untreated) and inoculated into the MDCK cells. The virus titers were measured at 5 dpi. b) Log10 reduction in titers as indicated in the legend of Table 1. c) In effect, a period of 10 sec was required to start the first dilution of the mixture immediately after mixing. d) See the description of d) in the legend of Table 1.