Table 2. Blood pressure, body tempreture and heart rate of mAb injected cats.
| Dose of mAb (mg/ml) |
Parameter | First injection (Day 0) |
Second injection (Day 14) |
Third injection (Day 28) |
Fourth injection (Day 42) |
Fifth injection (Day 72) |
||
|---|---|---|---|---|---|---|---|---|
| PBS (control) | 0 | Blood pressure (systolic blood pressure/diastolic blood pressure, mmHg) | Pre injectiona) | 182.0/162.7 | 162.3/129.7 | 169.3/140.7 | 179.7/152.0 | 163.7/140.0 |
| Post injectionb) | 164.0/146.3 | 156.0/142.0 | 156.3/139.0 | 158.3/131.7 | 209.7/139.7 | |||
| Body tempreture (°C) | Pre injectiona) | 39.2 | 38.6 | 38.9 | 38.8 | 39.0 | ||
| Post injectionb) | 38.2 | 38.0 | 38.0 | 38.3 | 37.4 | |||
| Heart rate (BPM) | Pre injectiona) | 138.0 | 130.0 | 151.0 | 115.3 | 121.0 | ||
| Post injectionb) | 136.3 | 140.7 | 140.7 | 113.7 | 114.7 | |||
| Mouse mAb 2–4 | 1 | Blood pressure (systolic blood pressure/diastolic blood pressure, mmHg) | Pre injectiona) | 192.3/162.7 | 156.0/130.7 | 151.3/117.0 | 179.0/165.0 | 169.3/113.0 |
| Post injectionb) | 156.0/126.7 | 168.0/116.7 | 143.0/121.0 | 208.7/168.7 | 156.7/114.0 | |||
| Body tempreture (°C) | Pre injectiona) | 39.3 | 38.7 | 38.2 | 38.8 | 39.0 | ||
| Post injectionb) | 38.0 | 36.9 | 36.1 | 37.5 | 38.9 | |||
| Heart rate (BPM) | Pre injectiona) | 128.7 | 135.3 | 125.0 | 114.0 | 136.3 | ||
| Post injectionb) | 129.0 | 115.7 | 127.0 | 114.3 | 128.0 | |||
| 5 | Blood pressure (systolic blood pressure/diastolic blood pressure, mmHg) | Pre injectiona) | 160.7/134.0 | 161.3/116.3 | 159.7/135.0 | 189.7/156.0 | 153.3/95.0 | |
| Post injectionb) | 148.7/128.7 | 170.7/152.0 | 145.3/93.3 | 126.3/98.3 | 165.0/93.3 | |||
| Body tempreture (°C) | Pre injectiona) | 38.6 | 37.7 | 37.3 | 38.6 | 38.8 | ||
| Post injectionb) | 38.0 | 37.7 | 36.9 | 38.3 | 38.2 | |||
| Heart rate (BPM) | Pre injectiona) | 141.0 | 142.0 | 127.0 | 146.0 | 145.0 | ||
| Post injectionb) | 144.7 | 131.3 | 131.7 | 140.7 | 138.7 | |||
| Chimeric mAb 2–4 | 1 | Blood pressure (systolic blood pressure/diastolic blood pressure, mmHg) | Pre injectiona) | 160.7/132.3 | 186.7/161.7 | 196.7/146.0 | 188.0/157.3 | 168.7/136.0 |
| Post injectionb) | 161.3/113.0 | 149.3/128.3 | 140.7/120.3 | 161.7/127.3 | 142.7/120.3 | |||
| Body tempreture (°C) | Pre injectiona) | 38.6 | 38.9 | 38.3 | 38.5 | 38.6 | ||
| Post injectionb) | 37.5 | 37.9 | 36.8 | 37.9 | 37.9 | |||
| Heart rate (BPM) | Pre injectiona) | 105.0 | 141.3 | 141.7 | 108.0 | 115.0 | ||
| Post injectionb) | 86.7 | 138.0 | 132.0 | 120.3 | 113.0 | |||
| 5 | Blood pressure (systolic blood pressure/diastolic blood pressure, mmHg) | Pre injectiona) | 172.7/136.0 | 175.0/138.7 | 164.7/140.3 | 160.7/152.0 | 178.3/140.3 | |
| Post injectionb) | 149.3/103.3 | 163.3/143.3 | 149.0/113.3 | 175.3/147.0 | 148.3/99.3 | |||
| Body tempreture (°C) | Pre injectiona) | 39.8 | 38.7 | 39.1 | 39.4 | 39.2 | ||
| Post injectionb) | 38.1 | 38.4 | 38.2 | 38.2 | 38.7 | |||
| Heart rate (BPM) | Pre injectiona) | 146.3 | 153.0 | 139.0 | 116.3 | 131.3 | ||
| Post injectionb) | 145.0 | 148.0 | 134.7 | 115.7 | 135.7 |
a) Immediately before administration of PBS or mAb. b) 10 min after administration of PBS or mAb.