Table 1. Clinical summary data for paraplegic dogs without nociception due to spinal trauma transplanted with autologous neurogenically-induced bone marrow-derived mesenchymal stem cells.
| Case no | Signalment of the dog | Neurologic examination at the admission time | X-ray/MRI | Surgical procedure | Neurologic examination | ||||
|---|---|---|---|---|---|---|---|---|---|
| At the time of first cell trans. (42.day) | At the time of 2nd cell trans. (63. day) | After the second cell transplantation | |||||||
| 2. months | 5. months | 7. months | |||||||
| 1 | 5m MI mix breed HBC AT: 1wk |
G0, P0, N0 Sca (4)Scr (0) Mcr (−)Mca (+) |
T13 proc. artc. and lamina fracture MRI: Hyperintense lesion in T2W images, and right side dorsolateral compression |
T13 right HL | G1, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (1) Mcr (−), Mca(+) |
G1, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) There was no change at 12. Month |
| 2 | 2y FI husky HBC AT: 1d |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
T12-13 fracture and luxation, 2/3 compression | T12-13 proc. artc. stabilized with pin and tension wire, and HL, LW between T11-L1 | G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
||
| 3 | 6m FI mix breed HBC AT: 1d |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
L1 burst fracture | HL in T13-L1 and LW including T12-13-L1-2-3 | G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
||
| 4 | 7m MI mix breed HBC AT: 1d |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
T12-13 luxation 1/3 compression, L5 (1/3 compression) vertebral body fracture |
T12 dorsal L T12-13 and L5-6 proc. artc. pin tension wire |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
|
| 5 | 8m F mix breed HBC AT: 1d |
G0, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
L2 (2/3 compression) and L7 (2/3) vertebral body fracture | L on L2-3, and stabilization with screw and PMMA, and
proc. artc. Lag screw fixation of L7-S1 |
G1, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G2, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G2, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
G2, P0, N0 Sca (4), Scr (1) Mcr (−), Mca (+) |
|
| 6 | 2y FI mix breed Gunshot wound AT: 2d |
G0, P0, N0 Sca (2), Scr (0) Mcr (−), Mca (−) |
Pellet on T11 level at the left side | Pellet had taken off with HL | G0, P0, N0 Sca (2), Scr (0) Mcr (−), Mca (−) |
G1, P0, N0 Sca (2), Scr (0) Mcr (−), Mca (−) |
G1, P0, N0 Sca (2), Scr (0) Mcr (−), Mca (−) |
||
| 7 | 2.5m FI mix breed HBC AT: 2d |
G1, P0, N0 Sca (4), Scr (2) Mcr (−), Mca (+) |
L5 burst fracture | L4-5-6 sublaminar wiring, L4-5 left side HL |
G2, P0, N0 Sca (4), Scr (2) Mcr (−), Mca (+) |
G4, P1, N1 Sca (4), Scr (3) Mcr (+), Mca (+) |
G4, P1, N2 Sca (4), Scr (4) Mcr (+), Mca (+) |
G4, P1, N2 Sca (4), Scr (4) Mcr (+), Mca (+) |
G4, P1, N2 Sca (4), Scr (4) Mcr (+), Mca (+) |
| 8 | 8m FI mix breed HBC AT: 2d |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
T12-13 luxation, 1/3 compression | T12-13 proc. artc. pin and tension wire stabilisation T12-13 Left side mini HL and disk fenestration |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
| 9 | 1y MI pointer HBC AT: 2d |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
T9-10 luxation 1/3 compression | T9-10 proc. artc. pin and tension wire and Left side HL, and T8 –T11 screw + PMMA | G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca(+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
| 10 | 6m M mix breed HBC AT: 1d |
G0, P0, N0 Sca (1), Scr (0) Mcr (−), Mca (+) |
L5 vertebral body fracture 1/3 compression |
L4-5 right side H, vertebral body reconstruction plate
and L4-5 proc. artc. pin tension wire, |
G1, P0, N0 Sca (4), Scr (3) Mcr (−), Mca (+) |
G3, P0, N1 Sca (4), Scr (3) Mcr (−), Mca(+) |
G3, P1, N2 Sca (4), Scr (4) Mcr (+), Mca (+) |
G3, P1, N2 Sca (4), Scr (4) Mcr (+), Mca (+) |
G3, P1, N2 Sca (4), Scr (4) Mcr (+), Mca (+) |
| 11 | 8y F mix breed, HBC and Operated 1 year ago due to Scrinal trauma AT: 1 year |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
MRI: Epidural fibrosis on T12 level Hyperintense lesion on T2 W 17 mm long at the Scrinal cord |
HL | G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca(+) |
G2, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G2, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G2, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
| 12 | 4m FI mix breed HBC AT: 2d |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
L3-4 luxation 2/3 compression |
L and Screw+PMMA in L2-5 | G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
| 13 | 4y M mix breed HBC AT: 1 Month |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
T12-13 fracture and luxation: 1/3 compression | L | G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G0, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
G1, P0, N0 Sca (4), Scr (0) Mcr (−), Mca (+) |
artc.: articularis; AT: Admission Time; FI: Female intact; G: Gait score; HBC: Hit by car, HL: Hemilaminectomy; L: Laminectomy; Lt: Left; LW: Laminotransversal wiring; Mca: MEP caudal; MI: Male intact; Mcr: MEP cranial; N: Nociception; P: Proprioception, PMMA: polymethylmethacrylate; proc.: processus; Rt: Right; Sca: SEP caudal; Scr: SEP cranial; trans.: Transplantation; y: years.