Table 1. Top 20 up-regulated genesa) in bovine mammary epithelial cells stimulated with lipoteichoic acid.
| Gene symbol | Gene name | Gene accession | Immune response | Inflammatory response | Log FC | P-valueb) | Common with FKSAc) stimulation |
|---|---|---|---|---|---|---|---|
| IL8 | interleukin 8, chemokine (C-X-C motif) ligand 8 (CXCL8) | NM_173925.2 | Yes | Yes | 6.1 | 3.20E-25 | Yes |
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | NM_174300.2 | Yes | Yes | 4.14 | 6.10E-78 | Yes |
| MCM7 | minichromosome maintenance complex component 7 | NM_001025345.2 | 3.66 | 0.03 | |||
| MX2 | myxovirus (influenza virus) resistance 2 (mouse) | NM_173941.2 | 2.73 | 0.0089 | Yes | ||
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | NM_001045868.1 | 1.53 | 0.0065 | |||
| RSAD2 | radical S-adenosyl methionine domain containing 2 | NM_001045941.1 | Yes | 1.43 | 0.0089 | ||
| CCL2 | chemokine (C-C motif) ligand 2 | NM_174006.2 | Yes | Yes | 1.37 | 3.90E-13 | Yes |
| IL1A | interleukin 1, alpha | NM_174092.1 | Yes | Yes | 1.2 | 0.0019 | Yes |
| MOV10 | Mov10 RISC complex RNA helicase | NM_001075839.1 | 1.19 | 0.017 | |||
| PRKCSH | protein kinase C substrate 80K-H | NM_176662.1 | 0.96 | 0.028 | |||
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | NM_174726.1 | Yes | 0.92 | 8.80E-07 | Yes | |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | NM_174445.2 | 0.88 | 0.0021 | Yes | ||
| RPS2 | ribosomal protein S2 | NM_001033613.1 | 0.86 | 0.033 | |||
| ZNF706 | zinc finger protein 706 | NM_001199073.1 | 0.8 | 0.022 | |||
| LOC504599 | histone H3.2 | NM_001166569.1 | 0.77 | 0.022 | |||
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | NM_001079779.1 | 0.74 | 0.023 | |||
| ADM | adrenomedullin | NM_173888.3 | 0.72 | 0.0065 | |||
| LOC505183 | histone H2B type 1-like | XM_581429.4 | 0.66 | 0.024 | |||
| HIST1H2AC | histone cluster 1, H2ac | XM_603142.2 | 0.61 | 0.033 | |||
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | NM_174267.2 | 0.61 | 0.0008 |
a) Up-regulated genes showing a value greater than 1 log FC, defined as the logarithm of the gene expression level in a sample relative to that of the non-stimulated control. b) Significance of the difference in gene expression levels between the sample and control. c) Formalin-killed Staphylococcus aureus.