Table 2. Top 20 up-regulated genesa) in bovine mammary epithelial cells following stimulation with formalin-killed Staphylococcus aureus.
| Gene symbol | Gene name | Gene accession | Immune response | Inflammatory response | Log FC | P-valueb) | Common with LTAc) stimulation |
|---|---|---|---|---|---|---|---|
| IL8 | interleukin 8,chemokine (C-X-C motif) ligand 8 (CXCL8) | NM_173925.2 | Yes | Yes | 4.92 | 1.90E-10 | Yes |
| SPP1 | secreted phosphoprotein 1 | NM_174187.2 | Yes | 3.51 | 5.90E-39 | ||
| ANKRD37 | ankyrin repeat domain 37 | NM_001075392.1 | 3.07 | 0.0089 | |||
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | NM_174300.2 | Yes | Yes | 2.74 | 1.60E-24 | Yes |
| C29H11orf86 | chromosome 29 open reading frame, human C11orf86 | NM_001077090.1 | 2.7 | 0.035 | |||
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | NM_175777.3 | 2.66 | 0.0035 | |||
| MX2 | myxovirus (influenza virus) resistance 2 (mouse) | NM_173941.2 | 2.57 | 0.013 | Yes | ||
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42 kDa, V1 subunit C1 | NM_176676.1 | 2.07 | 0.045 | |||
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | NM_001075628.2 | Yes | 2.07 | 0.015 | ||
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | NM_001192294.1 | 1.65 | 0.0043 | |||
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | NM_174445.2 | 1.49 | 2.20E-12 | Yes | ||
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | NM_174267.2 | 1.11 | 4.90E-11 | |||
| CCL2 | chemokine (C-C motif) ligand 2 | NM_174006.2 | Yes | Yes | 1.07 | 0.013 | Yes |
| IL1A | interleukin 1, alpha | NM_174092.1 | Yes | Yes | 1.02 | 0.032 | Yes |
| C27H8orf4 | chromosome 27 open reading frame, human C8orf4 | NM_001035490.2 | 1.01 | 5.00E-09 | |||
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | NM_174726.1 | Yes | 0.83 | 0.00019 | Yes | |
| DUSP6 | dual specificity phosphatase 6 | NM_001046195.1 | 0.78 | 8.40E-05 | |||
| MASTL | microtubule associated serine/threonine kinase-like | NM_001113765.1 | 0.71 | 0.011 | |||
| SIK1 | salt-inducible kinase 1 | XM_003581774.1 | 0.67 | 0.0024 | |||
| BCL3 | B-cell CLL/lymphoma 3 | NM_001205993.1 | Yes | 0.64 | 0.023 |
a) Up-regulated genes showing a value greater than 1 log FC, defined as the logarithm of the gene expression level in a sample relative to that of the non-stimulated control.b) Significance of the difference in gene expression levels between the sample and control. c) Lipoteichoic acid.