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. 2016 May 20;78(9):1505–1510. doi: 10.1292/jvms.15-0706

Table 2. Top 20 up-regulated genesa) in bovine mammary epithelial cells following stimulation with formalin-killed Staphylococcus aureus.

Gene symbol Gene name Gene accession Immune response Inflammatory response Log FC P-valueb) Common with LTAc) stimulation
IL8 interleukin 8,chemokine (C-X-C motif) ligand 8 (CXCL8) NM_173925.2 Yes Yes 4.92 1.90E-10 Yes
SPP1 secreted phosphoprotein 1 NM_174187.2 Yes 3.51 5.90E-39
ANKRD37 ankyrin repeat domain 37 NM_001075392.1 3.07 0.0089
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) NM_174300.2 Yes Yes 2.74 1.60E-24 Yes
C29H11orf86 chromosome 29 open reading frame, human C11orf86 NM_001077090.1 2.7 0.035
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 NM_175777.3 2.66 0.0035
MX2 myxovirus (influenza virus) resistance 2 (mouse) NM_173941.2 2.57 0.013 Yes
ATP6V1C1 ATPase, H+ transporting, lysosomal 42 kDa, V1 subunit C1 NM_176676.1 2.07 0.045
ERAP2 endoplasmic reticulum aminopeptidase 2 NM_001075628.2 Yes 2.07 0.015
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 NM_001192294.1 1.65 0.0043
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) NM_174445.2 1.49 2.20E-12 Yes
CEBPD CCAAT/enhancer binding protein (C/EBP), delta NM_174267.2 1.11 4.90E-11
CCL2 chemokine (C-C motif) ligand 2 NM_174006.2 Yes Yes 1.07 0.013 Yes
IL1A interleukin 1, alpha NM_174092.1 Yes Yes 1.02 0.032 Yes
C27H8orf4 chromosome 27 open reading frame, human C8orf4 NM_001035490.2 1.01 5.00E-09
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta NM_174726.1 Yes 0.83 0.00019 Yes
DUSP6 dual specificity phosphatase 6 NM_001046195.1 0.78 8.40E-05
MASTL microtubule associated serine/threonine kinase-like NM_001113765.1 0.71 0.011
SIK1 salt-inducible kinase 1 XM_003581774.1 0.67 0.0024
BCL3 B-cell CLL/lymphoma 3 NM_001205993.1 Yes 0.64 0.023

a) Up-regulated genes showing a value greater than 1 log FC, defined as the logarithm of the gene expression level in a sample relative to that of the non-stimulated control.b) Significance of the difference in gene expression levels between the sample and control. c) Lipoteichoic acid.