Figure 1.

Mitochondrial membrane potential is lower in synuclein-deficient cells and can be rescued by exogenous monomeric α-synuclein. A, Basal Δψm was quantified in WT, AKO, and TKO cells. B, Representative traces of TMRM fluorescence in WT and TKO primary cells after addition of oligomycin (2 μg/ml), rotenone (1 μm), and FCCP (1 μm). C, Representative images of cells loaded with TMRM before and after α-synuclein addition. *p < 0.05; ***p < 0.001; n = 3 independent experiments. Scale bar, 20 μm.