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. 2016 Oct 5;7:12992. doi: 10.1038/ncomms12992

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Each bar of whole-chromosome represents the expected (assuming uniform, random distribution, green) and the observed (actual numbers, tumour: blue, normal liver tissue: purple) ratio of HBV integration breakpoints at a particular chromosome in human genome. Ratios are numbered. Each bar of chromosomal ends represents the expected (assuming uniform, random distribution, green) and the observed (actual numbers, tumor: blue, normal liver tissue, purple) ratio of HBV integration breakpoints at the 2 M region of chromosomal ends in human genome. Ratios are numbered. Dark red star represents statistically significant difference between normal liver samples and random distribution. Blue star represents statistically significant difference between tumour samples and random distribution. P values were calculated by χ² test.