Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 5;7:12942. doi: 10.1038/ncomms12942

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

FS (CYP76AH1) oxidizes abietatriene to ferruginol, whereas HFS (CYP76AH22-24) are able to further oxidize ferruginol to 11-hydroxyferruginol. 11-hydroxyferruginol spontaneously oxidizes to hydroxyferruginol quinone. The C₂₀Ox (CYP76AK6-8) ensure conversion of 11-hydroxyferruginol to CA, which itself spontaneously oxidizes to carnosol. C₂₀Ox can also oxidize miltiradiene and ferruginol, the latter leading to PA, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate. The size of the arrows illustrates non-quantitatively the efficiency of the corresponding reactions.