Table 2.
Adjusted odds ratios of endorsing intention to quit smoking within next 30 days among current smokers with or without fixed airflow obstruction, by symptoms and markers of disease severity
| Variable | All Smokers (n = 338) |
Subjects with COPD Based on PFT (n = 194) |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | |
| GOLD stage | ||||||
| 0 (no COPD) | Reference | — | — | |||
| I–II (mild to moderate) | 1.85 | 1.37–2.49 | <0.001 | Reference | ||
| III–IV (severe to very severe) | 1.11 | 0.66–1.87 | 0.694 | 0.67 | 0.38–1.17 | 0.157 |
| Phlegm most days | 2.10 | 1.22–3.64 | 0.007 | 2.41 | 1.37–4.24 | 0.034 |
| Cough most days | 1.74 | 1.01–2.99 | 0.045 | 2.15 | 1.06–4.36 | 0.034 |
| Wheeze frequently | 1.73 | 1.09–3.18 | 0.023 | 1.98 | 0.94–4.18 | 0.071 |
| mMRC dyspnea scale, per point higher* | 1.26 | 1.13–1.41 | <0.001 | 1.22 | 1.05–1.42 | 0.008 |
| Exacerbation in past 3 mo | 0.92 | 0.63–1.33 | 0.645 | 1.62 | 0.64–4.08 | 0.308 |
| Prescribed home oxygen | 1.85 | 0.90–3.76 | 0.090 | 1.79 | 1.04–3.09 | 0.036 |
| Reported physician-diagnosed COPD, emphysema, or chronic bronchitis | 0.97 | 0.69–1.38 | 0.874 | 1.34 | 0.73–2.44 | 0.348 |
| FACIT dyspnea score† | ||||||
| ≤40 | Reference | Reference | ||||
| 40–49 | 1.35 | 0.80–2.28 | 0.264 | 1.42 | 0.57–3.53 | 0.453 |
| ≥50 | 1.84 | 0.92–3.70 | 0.087 | 2.00 | 0.86–4.68 | 0.105 |
| PROMIS score, physical function‡ | ||||||
| ≥42 | Reference | Reference | ||||
| 35–42 | 1.47 | 0.85–2.55 | 0.168 | 2.05 | 1.06–3.97 | 0.033 |
| ≤35 | 1.12 | 0.52–2.42 | 0.775 | 1.06 | 0.51–2.19 | 0.881 |
| EQ-5D-5L, self-reported health, 0–100 from worst to best |
||||||
| ≥80 | Reference | Reference | ||||
| 60–80 | 1.35 | 0.80–2.26 | 0.257 | 1.00 | 0.70–1.44 | 0.984 |
| ≤60 | 0.75 | 0.62–0.92 | 0.005 | 0.67 | 0.49–0.92 | 0.012 |
Definition of abbreviations: CI = confidence interval; COPD = chronic obstructive pulmonary disease; EQ = EuroQol; FACIT = Functional Assessment of Chronic Illness Therapy; GOLD = Global Initiative for Chronic Obstructive Lung Disease; mMRC = modified Medical Research Council; OR = odds ratio; PFT = pulmonary function testing; PROMIS = Patient Reported Outcomes Measurement Information System.
Models are adjusted for age, race, education, cigarettes smoked daily, GOLD stage, hours spent with another smoker, and comorbidities, clustered by site. Bold type indicates statistically significant values.
n = 333 and n = 191 for all smokers and subjects with COPD, respectively, due to missingness.
Normalized against an average of 50, with higher score meaning more dyspnea.
Normalized against an average of 50, with lower score meaning worse physical function.