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. 2016 Sep 28;2016:6786245. doi: 10.1155/2016/6786245

Figure 3.

Figure 3

Substrate specificity of the ABCD transporters. ABCD1–3 predominately exist as a homodimer. ABCD1 and ABCD2 have overlapping substrate specificities toward saturated and monounsaturated VLCFA-CoAs. However, ABCD1 has a higher specificity to C24:0-CoA and C26:0-CoA than ABCD2. In contrast, ABCD2 has a higher specificity for polyunsaturated C22:6-CoA and C24:6-CoA. ABCD3 is thought to be involved in the transport of LCFA-CoA, branched chain acyl-CoA, and the bile acid intermediates, THCA-CoA and DHCA-CoA. ABCD4 is deduced to be involved in the transport of cobalamin from lysosomes to the cytosol.