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. 2016 Sep 28;2016:1939052. doi: 10.1155/2016/1939052

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Copyright © 2016 Chih-Hsiang Hsu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The schematic diagram illustrates the possible neuroprotective pathways of B401 treatment in the brain tissue of 3× Tg-AD mice. 3× Tg-AD mice under oral herbal formula B401 treatment enhance neuroprotection via increasing expression levels of BDNF, VEGF, and antioxidative SOD2 and alleviate neurodegeneration via suppressing ROS production, decreasing expression levels of Aβ, p-Tau, NFTs, and oxidation-related 3-NT. Taking these effects, the herbal formula B401 may alleviate cognitive deficits in 3× Tg-AD mice.