Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 28;2016:1939052. doi: 10.1155/2016/1939052

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Chih-Hsiang Hsu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Oral B401 treatment effectively improves subcutaneous microcirculation and enhances brain VEGF expression in 3× Tg-AD mice. (a) (A) Dorsal subcutaneous microcirculatory flow imaging in 3× Tg-AD mice and their control (non-AD mice) by using moorFLPI laser Doppler imager. (B) Quantified dorsal subcutaneous microcirculatory flow in 3× Tg-AD mice with oral B401 treatment was significantly greater compared to those 3× Tg-AD mice with sham treatment. (b) Western blotting analysis shows the following. (A) Whole brain VEGF expression levels of 3× Tg-AD mice and their control. (B) Quantified brain VEGF levels of the 3× Tg-AD mice with oral B401 treatment were significantly greater compared to those 3× Tg-AD mice with sham treatment and their control. Results were shown as mean ± SEM (^∗∗ P < 0.01; ^∗ P < 0.05, one-way ANOVA followed by a Student-Newman-Keuls multiple comparisons post test), and the number of experiments was six for each treatment.