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. 2016 Sep 28;2016:1939052. doi: 10.1155/2016/1939052

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Copyright © 2016 Chih-Hsiang Hsu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oral B401 treatment effectively reduces blood ROS and enhances SOD2 but decreases 3-NT expressions in the brain of 3× Tg-AD mice. (a) (A) Blood ROS corresponding to the brain in 3× Tg-AD mice and their control (non-AD mice) by using chemiluminescence analysis. (B) Quantified blood ROS in 3× Tg-AD mice with oral B401 treatment were significantly decreased compared to those 3× Tg-AD mice with sham treatment but were greater compared to their control. (b) IHC staining shows SOD2 expression (marked by arrows) and (c) 3-NT expression (marked by arrows) in CA1 and dentate gyrus areas of 3× Tg-AD mice and their control (non-AD mice). Scale bars: 30 μm. (d) Western blotting analysis shows the following. (A) Whole brain SOD2 and 3-NT expression levels of 3× Tg-AD mice and their control. (B) Quantified brain SOD2 levels of the 3× Tg-AD mice with oral B401 treatment were significantly increased, but brain 3-NT levels were significantly decreased compared to those 3× Tg-AD mice with sham treatment. Results were shown as mean ± SEM (^∗ P < 0.05; ^∗∗ P < 0.01, one-way ANOVA followed by a Student-Newman-Keuls multiple comparisons post test), and the number of experiments was six for each treatment.