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. 2016 Sep 28;2016:1939052. doi: 10.1155/2016/1939052

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Copyright © 2016 Chih-Hsiang Hsu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oral B401 treatment effectively inhibits brain NFTs expression in 3× Tg-AD mice. (a) IHC staining shows NFTs expression (marked by brown color) in hippocampal CA1 and dentate gyrus (DG) areas of 3× Tg-AD mice with and their control (non-AD mice). Scale bars: 30 μm. (b) Western blotting analysis shows the following. (A) Whole brain NFTs expression levels of 3× Tg-AD mice and their control. (B) quantified brain NFTs levels of 3× Tg-AD mice with oral B401 treatment were significantly less than those 3× Tg-AD mice with sham treatment but were significantly greater than their control. Results were shown as mean ± SEM (^∗∗ P < 0.01; ^∗ P < 0.05, one-way ANOVA followed by a Student-Newman-Keuls multiple comparisons post test), and the number of experiments was six for each treatment.