Table 3.
Case #3: summary of pertinent laboratory results and imaging findings.
| Lab work/imaging (normal values) |
Baseline (within 3 mo before Radium-223) |
Interim (between injections #3 and #4) |
Completion (within 3 mo after Radium-223) |
|---|---|---|---|
| Hb (12.9–16.9/dL) |
11.5 | 10.9 | 8.5 |
| Platelets (156–369 × 109/L) |
231 | 273 | 157 |
| Absolute neutrophils (2.240–7.680 × 109/L) |
4.3 | 5.3 | 5.5 |
| PSA (ng/mL) |
33 | 119 | 597 |
| Alkaline phosphatase (38–126 IU/L) |
56 | 69 | 246 |
| Whole-body bone scan | Widespread bone metastases with the most intense lesions located along the T-spine, left skull, and ribs | Previous bone metastases show interval decrease in uptake. There are new bone metastases at other sites (upper T-spine, L-spine, pelvis, and ribs) | |
| Diagnostic CT-chest, abdomen, and pelvis | Widespread bone metastases consistent with bone scan. Several small liver lesions suspicious for metastases. No evidence of lymphadenopathy | Stable osteoblastic metastases. New areas of mild osteosclerosis in T-spine and L- spine consistent with bone scan findings. Also, worsening of liver metastases and suspicious new pulmonary metastases |