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Oral Glucose tolerance test ((a) and (b)) and insulin ((c) and (d)) in the GK+/−ApoE−/− mice compared with the ApoE−/− mice after 14 weeks on Western diet. Both male and female GK+/−ApoE−/− mice display significantly impaired glucose-stimulated insulin secretion. Values are presented as means and standard error of mean (SEM). ∗ p < 0.05, ∗∗ p < 0.005, and ∗∗∗ p < 0.0001.
