Figure 6.

The atherosclerotic lesions of the brachiocephalic artery in both genotypes have become advanced and complicated after Lard and WD for 14 and 23 weeks, respectively. Large areas of the lesions consist of necrotic core and cholesterol clefts. (a) Only a few scattered macrophages (brown indicated by arrow on the figure) are detected by the macrophage antibody. (b) Smooth muscle cells (brown) are detected in the vessel wall by the alpha-actin antibody. A thin cap is sometimes seen in the lesions, indicated by arrow on the figure. Images in Figures 6(a) and 6(b) are consecutive sections from the same animal.