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. 2016 Sep 28;2016:8630961. doi: 10.1155/2016/8630961

Figure 7.

Figure 7

Nonfasting total plasma cholesterol measured after 7 weeks on Lard diet, 4 weeks after diet changed from Lard to WD or Lard to Chow, and 14 weeks after diet changed from Lard to WD or Lard to Chow (a). Plaque size in the brachiocephalic artery (b) and aortic sinus plaque size (c) measured after 14 weeks on Lard to WD or Lard to Chow diet in the atheroregression study. (a) Priming mice with Lard diet induced a 3-fold increase in total cholesterol and the levels remained the same after changing to WD, resulting in similar cholesterol levels at 7 weeks. Conversely, after switching from Lard to Chow diet, the total cholesterol levels decreased significantly in all groups. (b) Plaque sizes in the brachiocephalic artery in both diet groups were comparable, which indicates that the atherosclerosis did not regress on the Lard to Chow diet change. (c). Female GK+/−ApoE−/− mice show equal amount of plaque in the aortic sinus in the Lard to Chow group compared to the Lard to WD despite lower plasma cholesterol levels in both GK+/−ApoE−/− and ApoE−/− mice after dietary change (Lard to Chow diet). Statistical analysis was performed using t-test and a p value of less than 0.05 was considered significant. ∗ p < 0.05.