Table 1.
Lipid levels in GK+/−ApoE−/− and ApoE−/− mice on Lard and Western diet measured in the atheroprogression study.
| Diet | Gender | Time | Genotype | Cholesterol (mmol/L) | TG (mmol/L) | NEFA |
|---|---|---|---|---|---|---|
| Lard | Males | 3 weeks | ApoE−/− | 38.86 ± 1.11 | — | — |
| GK+/−ApoE−/− | 35.84 ± 1.91 | — | — | |||
| 7 weeks | ApoE−/− | 38.20 ± 1.46 | — | — | ||
| GK+/−ApoE−/− | 31.00 ± 1.52 | — | — | |||
| 14 weeks | ApoE−/− | 38.32 ± 1.48 | 1.21 ± 0.11 | 0.49 ± 0.02 | ||
| GK+/−ApoE−/− | 30.84 ± 1.81 | 0.86 ± 0.14 | 0.45 ± 0.02 | |||
| Females | 3 weeks | ApoE−/− | 25.88 ± 1.00 | — | — | |
| GK+/−ApoE−/− | 22.78 ± 1.73 | — | — | |||
| 7 weeks | ApoE−/− | 25.20 ± 0.97 | — | — | ||
| GK+/−ApoE−/− | 23.40 ± 1.12 | — | — | |||
| 14 weeks | ApoE−/− | 20.58 ± 0.62 | 0.52 ± 0.13 | 0.55 ± 0.04 | ||
| GK+/−ApoE−/− | 20.11 ± 0.82 | 0.27 ± 0.06 | 0.50 ± 0.03 | |||
|
| ||||||
| Western | Males | 3 weeks | ApoE−/− | 20.84 ± 1.21 | — | — |
| GK+/−ApoE−/− | 17.42 ± 2.47 | — | — | |||
| 7 weeks | ApoE−/− | 22.40 ± 0.75 | — | — | ||
| GK+/−ApoE−/− | 18.80 ± 2.82 | — | — | |||
| 21 weeks | ApoE−/− | 31.65 ± 2.16 | 0.82 ± 0.09 | 0.39 ± 0.02 | ||
| GK+/−ApoE−/− | 27.88 ± 2.78 | 0.81 ± 0.13 | 0.44 ± 0.02 | |||
| Females | 3 weeks | ApoE−/− | 17.54 ± 1.04 | — | — | |
| GK+/−ApoE−/− | 20.62 ± 1.19 | — | — | |||
| 7 weeks | ApoE−/− | 18.60 ± 0.51 | — | — | ||
| GK+/−ApoE−/− | 18.40 ± 1.08 | — | — | |||
| 21 weeks | ApoE−/− | 23.35 ± 1.57 | 0.36 ± 0.05 | 0.45 ± 0.03 | ||
| GK+/−ApoE−/− | 20.57 ± 2.45 | 0.38 ± 0.06 | 0.43 ± 0.03 | |||
Lard diet induced higher cholesterol levels than Western diet. There is a trend for ApoE−/− mice to have higher cholesterol, triglycerides, and nonesterified fatty acids (NEFA) levels compared with GK+/−ApoE−/−. Data presented as mean ± SEM.