Figure 5. Gene modules enriched in genes with different somatic mutations and gene expression levels between two PRAD prognostic groups.

(a) p_nr value of gene lists ranked by ΔS (SM, yellow) and Sp (GE, blue); vertical lines indicate the top ranking genes selected to be part of the corresponding gene modules. (b) Network of genes belonging to SM module (yellow), GE module (blue) or both (green); square/circle = the gene is/is not ranked by network-free statistics within the first M positions (M = module size); vertex size = the larger the size the higher the gene score (maximum between ΔS and Sp); pink border = genes that occur in at least 10 articles on PRAD (Supplementary Data S1–2). These results were obtained with STRING PPIs.