Table 2. Ranking of module genes with the highest occurrence in the literature of PRAD.
| Symbol | SM |
GE |
Occurrence | ||
|---|---|---|---|---|---|
| ΔS | Δf | Sp | lfcp | ||
| TP53 | 1 | 1 | 155 | 2401 | 2075 |
| PIK3CA | 85 | 104.5 | — | — | 935 |
| BIRC5 | — | — | 24 | 361 | 589 |
| PTGS2 | 30 | 64 | — | — | 465 |
| EZH2 | — | — | 57 | 412 | 395 |
| CDK2 | — | — | 172 | 3324 | 391 |
| CDK1 | — | — | 1 | 83 | 380 |
| BRCA2 | 82 | 125.5 | — | — | 376 |
| E2F1 | — | — | 44 | 235 | 305 |
| CCNB1 | — | — | 174 | 639 | 284 |
| CC-2 | — | — | 21 | 222 | 239 |
| SERPINB5 | — | — | 67 | 151 | 239 |
| CBX2 | — | — | 45 | 154 | 201 |
| SMAD4 | 20 | 64 | — | — | 139 |
| MEFV | 73 | 707.5 | — | — | 81 |
| HDAC6 | 42 | 64 | — | — | 48 |
| CHD1 | 55 | 64 | — | — | 29 |
| TRPS1 | 119 | 707.5 | — | — | 26 |
| IDH1 | 14 | 16.5 | — | — | 14 |
| MST1R | 39 | 64 | — | — | 13 |
The occurrence is reported as number of papers; the symbol “—” indicates genes not included in gene modules; these results are relative to STRING PPIs (Supplementary Data S1–2).