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. 2016 Oct 12;6:35278. doi: 10.1038/srep35278

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The power to detect an effect was estimated in dependence of the odds ratio (OR) and the effect allele frequency (EAF) using software Quanto (version 1.2.4 from May 2009). Parameters used for simulation: Binary (disease) phenotype, significance level α = 5·10⁻⁸, disease prevalence k_P = 0.1, log-additive genetic model, no gene-environment interaction. (A) Effective N_cases = 27,640, 1.5817 effective controls per effective case (corresponding to 43,718 effective controls), (B) Female N_cases = 12,160, 2.3968 female controls per female case (corresponding to 29,145 female controls).