Table 3. Regression analysis of psychiatric indices and ophthalmic parameters in women with dry eye disease (DED).

	Age	Schirmer test	Tear BUT	SPK	Severity of DED	Photophobia	HADS score	HADS–A score	HADS–D score
PSQI global score	0.155 (0.113)	0.161 (0.295)	−0.143 (0.228)	0.087 (0.377)	−0.030 (0.766)	−0.057 (0.569)	0.231 (0.000)	0.291 (0.004)	0.409 (0.000)
Sleep disturbance score	0.023 (0.811)	0.036 (0.815)	−0.135 (0.257)	0.119 (0.232)	−0.132 (0.181)	0.032 (0.748)	0.114 (0.263)	0.084 (0.415)	0.121 (0.233)
BathroomA	0.200 (0.040)	−0.013 (0.930)	−0.184 (0.112)	0.037 (0.708)	−0.121 (0.226)	0.100 (0.304)	0.193 (0.056)	0.181 (0.071)	0.166 (0.093)
Pain	−0.023 (0.813)	0.283 (0.060)	0.176 (0.139)	0.162 (0.107)	0.118 (0.236)	−0.024 (0.815)	−0.021 (0.842)	−0.011 (0.914)	−0.024 (0.813)
Subjective sleep score	−0.046 (0.637)	0.088 (0.554)	0.009 (0.942)	0.110 (0.271)	−0.013 (0.898)	−0.023 (0.813)	0.315 (0.002)	0.235 (0.021)	0.330 (0.001)
Sleep latency	0.014 (0.884)	−0.074 (0.633)	−0.061 (0.610)	0.123 (0.219)	−0.028 (0.781)	0.066 (0.514)	0.320 (0.002)	0.256 (0.012)	0.297 (0.003)
Bedtime	−0.048 (0.623)	0.065 (0.651)	0.182 (0.119)	0.146 (0.141)	0.088 (0.380)	−0.094 (0.343)	0.018 (0.856)	−0.026 (0.804)	0.056 (0.584)
Photophobia	0.045 (0.651)	−0.087 (0.578)	0.183 (0.134)	0.174 (0.086)	−0.181 (0.073)	—	−0.044 (0.660)	−0.092 (0.370)	0.010 (0.921)
HADS score	−0.199 (0.045)	0.071 (0.656)	−0.008 (0.948)	0.018 (0.858)	−0.006 (0.953)	—	—	0.892 (0.000)	0.923 (0.000)
HADS-A score	−0.221 (0.025)	−0.039 (0.811)	−0.023 (0.850)	−0.040 (0.695)	−0.099 (0.328)	—	—	—	0.625 (0.000)
HADS-D score	−0.141 (0.157)	0.135 (0.377)	0.006 (0.958)	0.068 (0.500)	0.080 (0.423)	—	—	—	—

Data show β values, with P-values in parentheses. All results were adjusted for age.

PSQI, Pittsburgh Sleep Quality Index; HADS, Hospital Anxiety and Depression Scale; HADS-A, HADS Anxiety subscale score; HADS-D, HADS Depression subscale score; BUT, break-up time; SPK, superficial punctuate keratitis.

^ASleep disturbance because of the need to use the bathroom at night.