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. 2016 Oct 12;6:35201. doi: 10.1038/srep35201

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Copyright © 2016, The Author(s)

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(a) The steady-state relative concentrations of mRNA (m) and protein (p) as a function of V. (b) The normalised outward conductance resulting from the values of p as a function of V. (c) The cell potential V obtained by solving the bioelectrical equation of Fig. 1 as a function of the equilibrium potential E_in parametrically in the outward to inward conductance ratio . The cases of positive (continuous curves) and negative (dashed curves) regulation are considered. For particular values of E_in and , the cell potential enters into a bistability region where three (polarised, unstable, and depolarised) values for V are possible. The vertical arrows show these potentials for the reference case considered here.

Inline graphic — (a) The steady-state relative concentrations of mRNA (m) and protein (p) as a function of V. (b) The normalised outward conductance resulting from the values of p as a function of V. (c) The cell potential V obtained by solving the bioelectrical equation of Fig. 1 as a function of the equilibrium potential E_in parametrically in the outward to inward conductance ratio . The cases of positive (continuous curves) and negative (dashed curves) regulation are considered. For particular values of E_in and , the cell potential enters into a bistability region where three (polarised, unstable, and depolarised) values for V are possible. The vertical arrows show these potentials for the reference case considered here.