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. 2016 Oct 6;7:12977. doi: 10.1038/ncomms12977

Figure 7. Insulin signalling was impaired in both the PP and PV zones of the liver in the LIrs1/2DKO mice under the HF diet condition.

Figure 7

(a) Phosphorylation and protein levels of IR, Irs1, Irs2 and Akt in the hepatic PP and PV zones of LIrs1/2DKO mice in the fasting state (n=6–8). (b) Expression levels of the gluconeogenic genes in the hepatic PP and PV zones of the LIrs1/2DKO mice in the fasting state (n=4–10). (c) Expression levels of SREBP1c, ACC and FAS genes in the hepatic PP and PV zones of LIrs1/2DKO mice in the fasting state (n=4–10). (d) Expression levels of PPARγ, FSP27 and CD36 genes in the hepatic PP and PV zones of LIrs1/2DKO mice in the fasting state (n=4–10). Results are represented as mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001, (Student's t-test was used to analyse the statistical significances of differences between two groups, and analysis of variance for the statistical significances of differences among multiple groups).