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. 2016 Oct 12;6:35316. doi: 10.1038/srep35316

Figure 5. MiR-155 enhanced microtubule formation by suppressing E2F2 transcription factor.

Figure 5

(a) Sequence alignment of the human miR-155-5p mature sequence with the binding sites of human E2F2 3′-UTR wild-type (WT) and mutant (Mut). (b) Changes in luciferase activity of the pGL3-E2F2-3′-UTR WT and Mut after co-transfection with pre-155-5p. (c,d) Representative microtubule formation of HUVECs after transfection with pre-155, pre-155 combined with E2F2 expression plasmid (pcDNA-E2F2) and empty pcDNA control. MiR-155 partially improved microtubule formation by inducing E2F2 degradation. Scale bars = 200 μm. All data are means ± SD. *P < 0.05.