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. 2016 Oct 12;6:35267. doi: 10.1038/srep35267

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cytotoxicity of free doxorubicin (DOX), free resveratrol (RES), mixture of free DOX and free RES (MIX) and DOX/RES-loaded nanoparticles (NPS) on the MDA-MB-231/ADR cells (panel A) and MCF-7/ADR cells (panel B) in 48 h at 37 °C. The caspase-3 activity in MDA-MB-231/ADR cells (panel C) and MCF-7/ADR cells (panel D) after cells were incubated with free DOX, free RES, MIX and NPS for 24 h. Data are mean ± SD. n = 3. *p < 0.05, **p < 0.01, vs same concentration of MIX. ^#p < 0.05, ^##p < 0.01, vs same concentration of free DOX. ^&p < 0.05, ^&&p < 0.01, vs same concentration of RES.