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. 2016 Oct 12;6:35267. doi: 10.1038/srep35267

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Panel (A) is living image pictures of DOX distribution at 24 h after DOX/RES-loaded NPS (10 mg DOX/kg, 30 mg RES/kg) and free DOX (10 mg/kg) were administered by tailvein injection. Panel (B) is the quantitative analysis of DOX distribution after DOX/RES-loaded NPS and free DOX were administered by tail vein injection in 24 h. Panel (C) is living image pictures of DOX distribution at 12 h, 24 h and 48 h after DOX/RES-loaded NPS were administered by tailvein injection. Panel (D) is the quantitative analysis of DOX distribution after NPS were administered by tail vein injection in 12 h, 24 h and 48 h. Data are mean ± SD. n = 3, *p < 0.05, **p < 0.01, vs free DOX.