Figure 3. Effect of VAP-1 inhibition on atherosclerotic plaque inflammation in LDLR^−/−ApoB^100/100 mice.

(A) Movat’s pentachrome (left column)- and Mac-3 (right column)-stained aortic ostium. I = intima, L = lumen, M = media. Scale bar, 200 μm. (B) Areal percentage of the aortic plaque occupied by Mac-3-positive macrophages and (C) intima-to-media ratio determined at the level of the aortic ostium after a 4 week treatment with the small molecular VAP-1 inhibitor, LJP1586 (n = 15), or saline (n = 10). Values are mean and error bars standard deviation. P values, non-paired t test.