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. 2016 Oct 12;6:35055. doi: 10.1038/srep35055

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Copyright © 2016, The Author(s)

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(a) Neurological score among groups. Garcia test was used to evaluate animalneurological function at 24, 48, and 72 h after SAH, there were significant difference among 3 groups at the same time point (*P < 0.05 vs Vehicle group). (b) Brain water content among groups. BWC in the left hemisphere (perforation side) was significantly reduced in the SAH + methazolamide group compared to the SAH + vehicle group at 24 h post-SAH (*P < 0.05). (c) The total movement distance in the SAH + vehicle group and SAH + methazolamide group, sham group showed a significant difference (*P < 0.01) at the day 3, 7, and 14. But SAH + methazolamide group improved significantly (^#P < 0.05) than the SAH + vehicle group. (d) The central grid time in the SAH + vehicle group and SAH + methazolamide group, sham group showed a significant difference (*P < 0.01) at the day 3, 7, and 14. But SAH + methazolamide group improved significantly (^#P < 0.05) than the SAH + vehicle group. N = 8 mice for each group (a,c,d) and n = 9 mice for each group (b).