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. 2016 Oct 7;7:12972. doi: 10.1038/ncomms12972

Figure 4. Effect of epidermal reduction of insulin signalling on wound healing.

Figure 4

(ac) Wound healing in larvae expressing InRDN in the epidermis. (a) Time-lapse images of wound healing in L3 larvae. (bc) Kinetics of wound closure. Time course of wound closure in (b) absolute (μm2) and (c) relative (%) wound area. In controls (n=10) wound closure was completed by 112±3 min and in A58>InRDN (n=9) by 189±3 min. (b,c) Mean±s.e.m. two-tailed Student's t-test, *P<0.05, **P<0.005 and ***P<0.0005. Scale bars, 20 μm. Transgene genotypes of larvae: Control (A58-Gal4, UAS-mCD8-GFP/+) and A58>InRDN (UAS-InRDN; A58-Gal4, UAS-mCD8-GFP).