Figure 1.

Metabolism of diindolylmethane from cruciferous vegetables. Diindolylmethane is an end product of the pH-dependent metabolism of indole-3-carbinol. The concentration of diindolylmethane is highest in liver, followed by lung, kidney, and heart and, to a lesser extent, brain and plasma. Concentrations are time dependent, as demonstrated in a mouse model after supplementation with pure crystalline DIM at a dosage of 250 mg/kg.²⁶