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. Author manuscript; available in PMC: 2017 Sep 2.
Published in final edited form as: Circ Res. 2016 Jul 28;119(6):764–772. doi: 10.1161/CIRCRESAHA.116.308904

Figure 4. Mice with upregulated compliant titin display enhanced exercise capacity in a treadmill test.

Figure 4

A–B) Time and distance of TtnΔIAjxn mice and TtnΔIAjxn mice constitutively expressing N2BAsc; C–D) Time and distance of TtnΔIAjxn mice and TtnΔIAjxn mice with inducible expression of N2BAsc. Data shown as mean ± SEM. (Constitutive: αMHC-Cre cRbm20ΔRRM+/−; inducible: αMHC–MerCreMer cRbm20ΔRRM+/−). (Vehicle: DMSO; Treatment: raloxifene, both administered IP daily for 8 days with exercise testing 28 days after last injection) Note that the IAjxn is also deleted from the skeletal muscles of these mice and that therefore future control experiments are needed on cardiac-specific TtnIAjxn deletion mice.