Table 1.

Hemodynamics. Data shown as mean ± SEM

	WT	TtnΔIAjxn	ΔIAjxn/ΔRRM
Echocardiography
n	8	8	8	Conscious
HR (bpm)	650.5 ± 10.3	650.5 ± 13.4	669.0 ± 9.3
FS (%)	65.2 ± 1.8	57.5 ± 3.2	52.4 ± 1.7**
LVID;d (mm)	2.7 ± 0.1	2.8 ± 0.2	3.0 ± 0.1
LVID;s (mm)	1.0 ± 0.1	1.2 ± 0.2	1.4 ± 0.1
LVPW;d (mm)	1.1 ± 0.03	1.2 ± 0.1	1.1 ± 0.1
LVPW;s (mm)	1.9 ± 0.1	1.8 ± 0.1	1.7 ± 0.1
LVDD/WT (ratio)	2.5 ± 0.2	2.6 ± 0.3	2.7 ± 0.1
Heart rate maintained at 450 ± 25 (bpm)
LA Diameter (mm)	2.4 ± 0.2	2.7 ± 0.1	2.9 ± 0.1	Anesthetized
MV Decel (ms)	25.9 ± 0.7	21.9 ± 1.0**	26.5 ± 1.5††
MV E (mm/s)	770.5 ± 37.2	835.4 ± 22.7	780.7 ± 28.0
MV A (mm/s)	621.6 ± 35.8	547.4 ± 14.2	650.9 ± 26.9†
MV E/A	1.3 ± 0.03	1.5 ± 0.04****	1.2 ± 0.03††††
Cardiac Catheterization
n	7	7	8
HR (BPM)	431.3 ± 7.0	457.1 ± 23.2	492.5 ± 8.1
ESP (mmHg)	94.4 ± 4.7	98.5 ± 7.0	93.5 ± 2.5
EDP (mmHg)	2.0 ± 4.4	3.7 ± 1.0	1.4 ± 0.6
dPmax (mmHg/sec)	6807.4 ± 431.4	8257.2 ± 667.2	9224.3 ± 261.0*
dPmin (mmHg/sec)	−8116.3 ± 415.4	−7073.2 ± 254.7	−8894.5 ± 205.9†††
ESV (uL)	34.5 ± 7.6	33.9 ± 3.2	25.1 ± 3.0
EDV (uL)	70.0 ± 7.6	73.6 ± 4.1	60.1 ± 3.6
SV (uL)	35.5 ± 1.3	39.7 ± 3.4	37.1 ± 1.9
EF (%)	54.0 ± 5.7	53.9 ± 3.5	62.2 ± 2.7
EA (mmHg/uL)	2.7 ± 0.2	2.3 ± 0.2	2.4 ± 0.2
Tau Glantz (ms)	12.2 ± 3.3	18.2 ± 4.5	9.8 ± 0.4
ESPVR	4.3 ± 0.6	2.9 ± 0.5	3.1 ± 0.3
EDPVR	0.03 ± 0.004	0.08 ± 0.01****	0.03 ± 0.004††††

Abbreviations: ΔIAjxn: (Ttn^ΔIAjxn); ΔRRM (αMHC-Cre cRbm20^ΔRRM+/−). For additional abbreviations, see Non-standard Abbreviations and Acronyms list. Statistical significance calculated with one-way ANOVA with Bonferroni correction.

^*p<0.05;

^**p<0.01;

^***p<0.001;

^****p<0.0001.

(*symbol versus WT; † symbol versus Ttn^ΔIAjxn. (1 symbol: p<0.05; 2 symbols: p<0.01; 3 symbols: p<0.001; 4 symbols: p<0.0001).)