Skip to main content
. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Mol Pharm. 2016 Jul 1;13(8):2833–2843. doi: 10.1021/acs.molpharmaceut.6b00436

Table 3.

Parameter estimates for three methods of TDI data analysis in RLM. Data are expressed as estimates ± standard error.

Rate constant MM quasi-irreversible EII quasi-irreversible Standard Replot (all data) Standard Replot (1st 3 pts)
KI1 (μM) 36.0 ± 14.2 3.82 ± 1.49 did not converge 2.2 ± 2.3
k6 (min−1) 0.30 ± 0.10 0.071 ±0.020
k7 (min−1) 0.12 ± 0.02 0.11 ±0.02
k6/KI2 (nM−1min−1 3.66 ±1.01
kinact (min−1) 0 0 0.058 ± 0.014
AICc −243.4 −247.4 N.A N.A

N.A.: not admitted