Table 3.
Parameter estimates for three methods of TDI data analysis in RLM. Data are expressed as estimates ± standard error.
| Rate constant | MM quasi-irreversible | EII quasi-irreversible | Standard Replot (all data) | Standard Replot (1st 3 pts) |
|---|---|---|---|---|
| KI1 (μM) | 36.0 ± 14.2 | 3.82 ± 1.49 | did not converge | 2.2 ± 2.3 |
| k6 (min−1) | 0.30 ± 0.10 | 0.071 ±0.020 | ||
| k7 (min−1) | 0.12 ± 0.02 | 0.11 ±0.02 | ||
| k6/KI2 (nM−1min−1 | 3.66 ±1.01 | |||
| kinact (min−1) | 0 | 0 | 0.058 ± 0.014 | |
| AICc | −243.4 | −247.4 | N.A | N.A |
N.A.: not admitted