Figure 5.

Effect of ANXA1 on p53 transcriptional activity. (a) ChIP-PCR analysis showing the combination of ANXA1 with Bid following treatment of HEK293 cells with ANXA1 overexpression and PFT-α. (b) Statistical analysis of the data shown in (a). The data are expressed as the means±S.E.M. from three independent experiments. *P<0.05 versus control and ^#P<0.05 versus ANXA1. (c) The luciferase assays show the transcriptional activity of p53 following treatment with ANXA1 after OGD/R in HEK293 cells. The data are expressed as the means±S.E.M. from three independent experiments. *P<0.05 versus control and ^#P<0.05 versus OGD/R. (d) The luciferase assays show the transcriptional activity of p53 following treatment with ANXA1 shRNA in HEK293 cells. The data are expressed as the means±S.E.M. from three independent experiments. *P<0.05 versus Scr and ^&P<0.05 versus Scr+OGD/R