Figure 4.

Induced glial reactivity promotes inner retinal apoptosis and is rescued by IF and p38 MAPK inhibition. (a) Schematic for induction of retinal gliosis by corneal debridement, followed by drug or vehicle treatments and KA challenge. (b and c) KA challenge induced rapid gliosis and GCL death as previously. (d and e) Prior corneal debridement-induced increased GFAP accumulation and increased GCL apoptosis following KA insult (arrows). Treatment with WFA (f and g) or SB (h and i) rescued the debridement-induced gliosis and cell death. (j and k) Quantification of the results showing that gliosis induced GCL death in WFA and SB-treated animals is significantly reduced (bars are S.E., **P<0.01, n⩾6 animals). Scale bar indicates 50 μm