Table 1. Clinical chemistry parameters.
| Metabolite |
Sham |
BDL day 3 |
BDL day 14 |
|||
|---|---|---|---|---|---|---|
| WT | RIP3−/− | WT | RIP3−/− | WT | RIP3−/− | |
| AST (U/l) | 128±34 | 128±26 | 760±60* | 424±101*† | 397±104* | 555±136* |
| ALT (U/l) | 26±6 | 23±2 | 514±40* | 295±63§† | 352±80* | 562±88* |
| AP (U/l) | 47±12 | 23±15 | 388±87* | 253±41* | 750±175* | 1572±255§† |
| Conj. bilirubin (mg/dl) | 0.05±0.01 | 0.05±0.01 | 5.0±1.5§ | 4.8±1.2§ | 5.4±2.0§ | 11.4±2.5§† |
| Total bilirubin (mg/dl) | 0.12±0.01 | 0.21±0.06 | 5.5±1.6§ | 5.9±1.6§ | 8.2±2.3§ | 13.9±1.9* |
Abbreviations: ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; Conj. bilirubin, conjugated bilirubin. §P<0.05 and *P<0.01 from sham-operated mice; †P<0.05 from BDL WT mice at respective time-point