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. 2016 Sep 29;7(9):e2383. doi: 10.1038/cddis.2016.291

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Proposed mechanism of activation of DDR through interaction of PLAUR and TLR4. Damage molecule serving as a ligand of PLAUR/TLR4 receptor complex is released from the cell nucleus. PLAUR/TLR4 auto-/paracrine signaling promotes CHK1 phosphorylation, activation and nuclear import of RAD51. Downregulation of PLAUR in TP53 WT cells results in delayed DNA repair and TP53-dependent cell cycle arrest and cell death. Cell cycle arrest in TP53-mutated PLAURsi cells is compromised and results in abnormal mitosis